cancer dairy consumption

2011;63(1):1220. Incidence rates of cancers (ICD-10 coded) at 30-79 years and adjusted HRs (95% CIs) for cancers per 50 g/day of usual dairy intake in men and women from CKB, without prior self-reported history of cancer at baseline. Arch Toxicol. Researchers who are interested in obtaining the raw data from the China Kadoorie Biobank study that underlines this paper should contact ckbaccess@ndph.ox.ac.uk. Diabetes care 2015;38:264-270. Zool Res. Fourth, there may be significant heterogeneity among the included studies due to reported population variations in terms of lifestyle preferences, living locations, and so on. Premenopausal fat intake and risk of breast cancer. In total, 12 studies investigated the relationship between high-fat dairy products and BC. Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200000 men in UK Biobank. Scientific report of the Dietary Guidelines Advisory Committee. 2013;167(3):9259. Figure 3. The primary objective was the risk of BC and intake of dairy products were exposure variables. https://doi.org/10.3892/ol.2019.9898. Maiji CDC: Zhongxiao Li, Enke Mao, Tao Wang, Hui Zhang, Xi Zhang; Hainan Provincial CDC: Jinyan Chen, Ximin Hu, Xiaohuan Wang. Measuring the impact of Georgia's consumption of 'forever chemicals'. To fully characterise valid associations between dairy consumption and risk of cancer and/or mortality rigorously conducted, PMASRs including only high-quality prospective study . Methods Study population. Role of cholesterol in the development and progression of breast cancer. Association Between Dairy Product Consumption and Colorectal Cancer Int J Cancer. Barzaman K, Karami J, Zarei Z, Hosseinzadeh A, Kazemi MH, Moradi-Kalbolandi S, et al. 2014;37(1):5663. The effect of consuming other types of dairy products did not differ by gender. Wu Y, Huang R, Wang M, Bernstein L, Bethea TN, Chen C, et al. According to the meta-analysis, low-fat dairy products were found to have no noticeable effect on all populations (HR=0.98, 95%CI=0.941.03, p=0.50) and postmenopausal population (HR=1.04, 95%CI=0.991.09, p=0.15). Obes Res Clin Pract. 2018;68(4):130818. Dairy consumption and risks of total and site-specific cancers in 2017;50(1):33. https://doi.org/10.1186/s40659-017-0140-9. The long-term follow-up has been supported by Wellcome grants to Oxford University (212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z) and grants from the National Key Research and Development Program of China (2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904) and from the National Natural Science Foundation of China (91843302). A schematic flow for the selection of articles included in this meta-analysis. Meat, eggs, dairy products, and risk of breast cancer in the European prospective investigation into Cancer and nutrition (EPIC) cohort. Dietary patterns and breast or lung cancer risk: a pooled analysis of 2 case-control studies in North-Eastern Poland. In this large prospective study of Chinese adults with relatively low dairy consumption, higher dairy consumption was associated with a higher risk of overall cancer, liver cancer, female breast cancer and lymphoma, with each 50-g/day higher usual intake being associated with 7%, 12%, 17% and 19% higher risks, respectively; however, the association with lymphoma became non-significant after multiple-testing correction. Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, et al. The China Kadoorie Biobank (CKB) is a global resource for the investigation of lifestyle, environmental, blood biochemical and genetic factors as determinants of common diseases. J Natl Cancer Inst. Part of The relationship between dairy products intake and breast cancer Curr Dev Nutr. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. 14. Gallardo M, Calaf GM. Nutrients. https://doi.org/10.1007/978-1-4615-2510-3_11. That information was used to estimate the mean usual amount of consumption (i.e. A nested case-control study of female breast cancer in Karunagappally cohort in Kerala. Is dairy intake associated to breast cancer? Pala V, et al. https://doi.org/10.1023/A:1021919416101. Cancer Res. rice, wheat products, coarse grain products, red meat, poultry, fish, eggs, total dairy products, fresh vegetables, preserved vegetables, fresh fruit and soybean products) [3] was obtained using a validated interviewer-administered laptop-based questionnaire. https://doi.org/10.1080/01635581.2011.570897. Kiecolt-Glaser, J.K., Fagundes C.P., Andridge R., Peng J., Malarkey W.B., Habash D., Belury M.A., Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices. Nevertheless, our study has several limitations. Article 2015;18(4):31322. J Hum Nutr Diet. Dairy consumption and calcium intake and risk of breast cancer in a prospective cohort: the Norwegian women and Cancer study. Eight meta-analyses 23 39 showed non-significant associations between whole milk, milk, low-fat milk, skim milk, yogurt, cheese, cottage cheese or ice cream consumption and risk of pancreatic cancer. Despite the recent increase, the incidence of colorectal and prostate cancers is still lower in China than in the West [4, 42, 43]. https://doi.org/10.1093/jnci/89.18.1373. Harding JL, Shaw JE, Peeters A, Cartensen B, Magliano DJ. Varinska L, Gal P, Mojzisova G, Mirossay L, Mojzis J. Soy and breast cancer: focus on angiogenesis. Consumption of dairy products in relation to changes in anthropometric variables in adult populations: a systematic review and meta-analysis of cohort studies. Biol Res. Yujing He, Qinghua Tao, and Bangsheng Chen manuscript writing; Feifei Zhou and Yuexiu Si performing procedures and data analysis; Rongrong Fu, Binbin Xu and Jiaxuan Xu contribution to writing the manuscript; Xiangyuan Li contribution to drafting conception and design. Higher whole milk consumption was linked to a higher mammography density associated with BC risk. Physiol Rev. Of the 36 included studies, 14 were cohort studies (912,975 participants and 25,097BC cases), and 22 were case-control studies (106,257 participants and 18,543BC cases). Health Concerns About Dairy - Physicians Committee for Responsible Medicine CLA is a mixture of positional and geometric isomers of linoleic acid, which are mainly from dairy products (60%) and beef products (32%) [100]. Available from: https://gco.iarc.fr/today. Aune D, Navarro Rosenblatt DA, Chan DS, Vieira AR, Vieira R, Greenwood DC, et al. 2015;95(3):72748. To quantify the linear association of dairy intake and cancer risk and to account for regression dilution bias, the mean usual consumption amount for each baseline group was estimated via combining the consumption level at both baseline and the second resurvey. Linear regression analyses were adjusted for age (continuous variable), region (ten regions), education (four categories), annual household income (four categories), smoking (four categories), alcohol consumption (four categories), total physical activity (continuous variable) and fresh fruit consumption (five categories). Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies. Li C, Yang L, Zhang D, Jiang W. Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. Dietary fats and prevention of type 2 diabetes. According to the quality evaluation results of the investigators, 13 studies out of 36 were rated 9 points, 16 studies were rated 8 points, 5 studies were rated 7 points and 2 studies were rated 6 points. 2016;11(6):e0157461. Dairy Consumption Linked to Lower Colorectal Cancer Risk Wednesday, 22 April 2020 Nutritional Science 5271 Hits By: Briana Granado. The second objective is to explore the effects of various dairy products, including fermented dairy products, non-fermented dairy products, high-fat dairy products and low-fat dairy products, on the incidence of BC. P-values less than 0.05 were considered statistically significant. 2017;147(4):64552. Asian Pac J Cancer Prev. Int J Cancer. Dairy products and the risk of stroke and coronary heart disease: the Rotterdam study. https://doi.org/10.7314/APJCP.2014.15.21.9543. Consumption of Dairy Products and the Risk of Developing Breast Cancer Mol Carcinog. Bangsheng Chen. Biosci Rep. 2020;40(12). 2017;67(5):37897. Declining incidence of breast cancer after decreased use of hormone-replacement therapy: magnitude and time lags in different countries. Risrus U, Willett WC, Hu FB. https://doi.org/10.1038/4441022a. Also reviewed are the reports over the years that have suggested milk and the dairy industry as responsible agents for causing . The recruitment process and characteristics of the AHS-2 cohort have been described previously. https://doi.org/10.1002/ijc.1409. Influence of food groups and food diversity on breast cancer risk in Italy. 15 Briefly, 52 795 female participants (aged 30 years and older) were recruited from . No studies exist with large numbers of dairy consumers and soy consumers to assess mutual confounding. Lima FE, et al. The y axis was plotted on a loge scale with the lowest intake group (never/rarely) as a reference category. Marcondes LH, et al. CAS Am J Epidemiol. Dairy, soy, and risk of breast cancer: those confounded milks N Engl J Med. Butler LM, Wong AS, Koh WP, Wang R, Yuan JM, Yu MC. Heterogeneity across included studies was tested by Q statistic and I2 statistic, which is a quantitative measure of inconsistency assessment. Schwingshackl L, Hoffmann G, Schwedhelm C, Kalle-Uhlmann T, Missbach B, Knppel S, et al. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. de Moreno de Leblanc A, et al. 1995;16(1):334. Dairy, soy, and risk of breast cancer: those confounded milks Huixian CDC: Yulian Gao, Tianyou He, Pan He, Chen Hu, Huarong Sun, Xukui Zhang; Hunan Provincial CDC: Biyun Chen, Zhongxi Fu, Yuelong Huang, Huilin Liu, Qiaohua Xu, Li Yin. 2023 BioMed Central Ltd unless otherwise stated. Consumption of fermented milk products and breast cancer: a case-control study in the Netherlands. Standing height and leg length were both positively associated with dairy consumption in both sexes, with regular consumers having 0.6 cm higher standing height and 0.3 cm higher leg length than non-consumers. Br J Nutr. Whether dairy products play a protective or harmful role against BC occurrence in female population is still controversial. Several large prospective studies, including meta-analyses of these studies, of primarily Western populations have examined the associations of dairy intake with cancer risks, showing an inverse association with colorectal cancer [6], positive association with risk of prostate cancer [7] but lack of clear associations with risks of breast [8] and many other site-specific cancers [9]. In contrast, low-fat dairy products can protect the premenopausal population and reduce the incidence rate of BC. In addition, the consumption of dairy products had no effect on the incidence of ER- BC (HR=1.06, p=0.42), PR- BC (HR=1.05, p=0.56) and ER/PR- BC (HR=0.96, p=0.36) BC. The maximum scores of this checklist were nine, and scores between six and nine were identified to higher study quality. A new study that suggests drinking dairy milk increases the risk of breast cancer is making headlines, but before you skip the milk in your smoothie, AICR experts say to consider the overall research. Laden F, Hankinson SE, Spiegelman D, Neas LM, Colditz GA, Hunter DJ, et al. Diabetologia. https://doi.org/10.7314/APJCP.2016.17.4.2035. Calculation of the usual amount of dairy intake and regression dilution bias correction. Jeyaraman MM, Abou-Setta AM, Grant L, Farshidfar F, Copstein L, Lys J, et al. https://doi.org/10.3343/alm.2020.40.2.114. Intakes of calcium and vitamin D and breast cancer risk in women. McCann SE, Hays J, Baumgart CW, Weiss EH, Yao S, Ambrosone CB. Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah-Muthu SS, Verschuren WMM, Boer JMA, et al. There was also a slightly higher proportion of regular consumers who self-reported prior history of cardiovascular disease or diabetes than non-consumers. Stat Med. A systematic review and meta-analysis. 11(8), Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study, 11, 8, doi: https://doi.org/10.3390/nu11081871. Kim MK, et al. 2012;10(3):299309. Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: a 7-y prospective study of 0.5 million Chinese adults. Frontiers | Dairy Product Consumption and Bladder Cancer Risk in the 2017;33:11724. Wang J, Li X, Zhang D. Dairy product consumption and risk of non-Hodgkin lymphoma: a meta-analysis. Because of their complex composition, no clear mechanism of action has been proposed to explain the contribution of dairy products to BC incidence [17]. 2003;327(7414):55760. https://doi.org/10.1146/annurev-med-051613-012328. Google Scholar. Plant-based milk less nutritious than cow's milk, finds research Gandini S, Merzenich H, Robertson C, Boyle P. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. International Agency for Research on Cancer. 2016;53(1):1523. On the contrary, low-fat dairy products can protect the premenopausal population (HR=0.94, 95%CI=0.891.00, p=0.048). Buja, A., et al., Breast Cancer Primary Prevention and Diet: An Umbrella Review. Nutr., 21 July 2020 Sec. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. The black squares represent HRs with the size being inversely proportional to the variance of the loge of HR and the vertical lines represent 95% CIs. The primary objective was the risk of BC and intake of dairy products were exposure variables. PMID: 32095830 PMCID: PMC8453418 DOI: 10.1093/ije/dyaa007 Abstract Background: Associations between soy, dairy intakes and breast cancer risk are inconsistent. Int J Epidemiol. Eur J Cancer. Fatal and non-fatal events were International Classification of Diseases (ICD)-10 coded by trained staff, who were blinded to baseline information [18]. Article Cookies policy. from baseline to resurvey) in participants with higher dairy intake are also consistent with previous results from observational studies and randomized controlled trials [26, 27], supporting the role of dairy products in slowing down bone loss. J Natl Cancer Inst. 2016;7(49):809809. Based on the results of this study, we recommend that women should be well suited to consume some dairy products, especially recommending low-fat dairy products for premenopausal women and fermented dairy products for postmenopausal women, minimizing the intake of high-fat dairy products, which may help to reduce the risk of BC. U.S. Breast Milk Contaminated by 25 Kinds of Flame Retardant Chemicals 2 and 3.Results from 10 studies on total dairy food intake were inconsistent, with most showing an inverse relation. https://doi.org/10.1158/1055-9965.EPI-17-0345. Int J Oncol. Terms and Conditions, The Life After Cancer Epidemiology study found that, among women previously diagnosed with breast cancer, those consuming one or more servings of high-fat dairy products (e.g., cheese, ice cream, whole milk) daily had a 49% higher breast cancer mortality, compared with those consuming less than one-half serving daily. Gu L, et al. For lymphoma, although regular dairy consumption was significantly associated with 23% (1.23; 1.041.46) higher risk, the P trend value became non-significant after FDR correction. Milk and dairy products: good or bad for human health? An assessment of The keywords we used for searching were breast cancer and dairy. Clin Nutr. For example, high cheese consumption was associated with an increased risk of death from colorectal cancer equally for men and women. Intake of dairy products and the risk of breast cancer. https://doi.org/10.3109/0284186X.2011.636754. Li J, Koh WP, Jin AZ, Yuan JM, Yu MC, Butler LM. A research proposal will be requested to ensure that any analysis is performed by bona fide researchers and where data is not currently available to open access researchers is restricted to the topic covered in this paper. Robien K, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's health study. 2007;335(7630):1134. https://doi.org/10.1136/bmj.39367.495995.AE. Analyses were stratified by age-at-risk (continuous), sex (dichotomous variable) and region (ten regions) and were adjusted for education (four categories), income (four categories), smoking (four categories), alcohol consumption (four categories), total physical activity (continuous variable), family history of cancer (dichotomous), fresh fruit consumption (five categories), soy consumption (three categories) and BMI (continuous variable). A jointly agreed data collection form was used to extract all data. The vital status of participants (including causes of deaths) was determined based on information from the Disease Surveillance Points system in China [21], checked annually against local residential records and health insurance records and confirmed by street committees or village administrators. Pierobon M, Frankenfeld CL. Colorectal cancer incidence in Asian migrants to the United States and their descendants. J Epidemiol Community Health. Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D, et al. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. https://doi.org/10.1016/j.breast.2017.03.012. https://doi.org/10.4048/jbc.2015.18.4.313. PubMed 2020;40(2):11421. Provided by the Springer Nature SharedIt content-sharing initiative. However, high-fat dairy products are harmful to female population, without statistically significant difference. Ip C, Chin SF, Scimeca JA, Pariza MW. Thirdly, we did not collect individual-level dairy consumption amount at baseline and the HRs for each 50 g/day of dairy consumption were estimated based on the assumption that the daily portions of dairy products did not change from baseline to the 2nd resurvey. https://doi.org/10.2337/dc13-0975. Information was extracted as follows: the authors name, year of publication, study type, country where the study was done, age, follow-up time, number of participants, number of BC cases identified in the study period, dairy type, and outcomes. Measuring the impact of Georgia's consumption of 'forever chemicals' Vitamin D, calcium and prevention of breast cancer: a review. 2014;72(1):117. Many studies have examined the relationship between. Prog Mol Biol Transl Sci. 2016;8(3):120. Kakkoura, M.G., Du, H., Guo, Y. et al. Lancet Gastroenterol Hepatol. https://doi.org/10.3945/an.117.017178. PubMed Most studies do not make special requirements for included participants, two studies were only conducted on nurses, and one study was only conducted in premenopausal population. Major risk factors for cancer include smoking, chronic infection, female reproductive factors, alcohol consumption and, potentially, certain dietary factors, including low intakes of fresh fruit, vegetables and whole grains and high intake of processed meat [3,4,5]. Am J Clin Nutr. 2017;9(7):9(7). Zhonghua Yu Fang Yi Xue Za Zhi. 2020;84:106535. https://doi.org/10.1016/j.intimp.2020.106535. 2014;15(21):95437. A third investigator resolved disagreements. Total dairy products have a protective effect on female population (hazard ratio (HR) =0.95, 95% confidence interval (CI) =0.910.99, p=0.019), especially for estrogen receptor-positive (ER+) (HR=0.79, p=0.002) and progesterone receptor-positive (PR+) BC (HR=0.75, p=0.027). Article 2000;36(5):63646. Hadadi E, Taylor W, Li XM, Aslan Y, Villote M, Rivire J, et al. Many studies have indicated that dairy products may also impact health problems such as obesity [47], diabetes [48, 49], cancer [50], and coronary heart disease [51, 52], but whether dairy products play a protective or harmful role against BC occurrence in female population is still controversial. Google Scholar. The multivariable-adjusted RRs for each study and all studies combined for the highest versus lowest categories of total dairy food and milk consumption in relation to breast cancer risk are shown in Figs. Kaluza J, Komatsu S, Lauriola M, Harris HR, Bergkvist L, Michalsson K, et al. https://doi.org/10.1007/BF01832358. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 1995;63(1):137. Dairy intake and risk of type 2 diabetes. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Based on the available evidence, the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) concluded that although the overall evidence on the dairy and cancer relationship is still inconsistent, there is strong evidence supporting the probable protective role of dairy products in the incidence of colorectal cancer and limited evidence suggesting that higher dairy intake is associated with higher prostate cancer risk [5]. Fidler MM, Gupta S, Soerjomataram I, Ferlay J, Steliarova-Foucher E, Bray F. Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study. Methods A search was carried out in PubMed, EBSCO, Web of Science, and Cochrane Library databases before January 2021. 2011;40(6):165266. For ER+/PR+ BC, a trend was observed towards lower risk with consuming dairy products, but the difference was not statistically significant (HR=0.92, p=0.075). Secondly, we could not assess the associations between different types of dairy products (i.e. The statistical packages SAS (version 9.4, SAS Institute, Cary, NC, USA) and R 3.6.3 (https://www.R-project.org/) were used for performing the analyses and creating the figures. We aimed to investigate the association between dairy intake and all-cause, cancer, and cardiovascular disease (CVD) mortality in Japanese adults. https://doi.org/10.3390/nu9070728. Two potential reasons exist for the detrimental effect of high-fat dairy products on female BC. Adjusted HRs (95% CIs) for female breast cancer per 50 g/day of usual dairy intake, with step-wise adjustment. Second, most studies assessed diet using self-reported FFQs based on their plausibility and reproducibility, although a few used interviews, implying that dietary assessment inevitably produces assessment or measurement error, most likely biasing the findings. Zong G, Sun Q, Yu D, Zhu J, Sun L, Ye X, et al. Huang L, Wang Z, Wang H, Zhao L, Jiang H, Zhang B, et al. 2017;2(10):73846. https://doi.org/10.1001/archinte.167.10.1050. Participants who had died (~9%) or were lost to follow-up (~1%) were censored in the prospective analyses (censoring date was 1 January 2018). In addition to these, studies have shown that dairy partial ingredients and their bioactive components can exert inhibitory effects on BC by downregulating ER-expression and activity, inhibiting proliferation, metastasis, and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest and sensitizing breast tumor cells to radiotherapy and chemotherapy, which may explain the reason why dairy products have apparent protective effects on hormone receptor-positive BC [33, 103,104,105]. He Y, Yang X, Xia J, Zhao L, Yang Y. Key and Zhengming Chen contributed equally to this work. 2011;127(1):2331. J Dairy Sci. Zang J, Shen M, du S, Chen T, Zou S. The association between dairy intake and breast Cancer in Western and Asian populations: a systematic review and Meta-analysis.