perna canaliculus for humans

Reduction in fecal microbiota diversity and short-chain fatty acid producers in methicillin-resistant staphylococcus aureus infected individuals as revealed by pacbio single molecule, real-time sequencing technology. Careers. Short-chain fatty acids (SCFAs) as signaling molecules affected end-organ health. The https:// ensures that you are connecting to the MeSH FOIA The .gov means its official. designed Figure 1. Ramsey SD, Spencer AC, Topolski TD, Belza B, Patrick DL. The black dots estimate the study result and give a representation of the size of the study. and transmitted securely. Furthermore, a recent study suggests that marine compounds such as the red seaweed Chondrus crispus presents evidence that when orally administered may act as a prebiotic [39]. Winter EM, Ireland A, Butterfield NC, Haffner-Luntzer M, Horcajada MN, Veldhuis-Vlug AG, Oei L, Colaianni G, Bonnet N. Endocr Connect. Kellow N.J., Coughlan M.T., Reid C.M. Gibson S.L.M., Gibson R.G. read, amended, and approved the final version of the manuscript. These studies should consider controlling for gender differences, monitor adverse effects, measure changes in gut microbiota, and employ standardised measurements for assessing OA symptoms. Natural medicines are often an attractive option for patients diagnosed with chronic conditions. The remaining 11 studies were selected for full-text reading and were also examined to ensure that the researchers had obtained ethical approval for the study. Comp. Additional studies are warranted to confirm the interaction of GSM bioactive compounds with intestinal microbiota. It has also been tried in humans to supplement allergic asthma treatment. Hutkins R.W., Krumbeck J.A., Bindels L.B., Cani P.D., Fahey G., Jr., Goh Y.J., Hamaker B., Martens E.C., Mills D.A., Rastal R.A., et al. Greenshell mussel; Joint pain; Osteoarthritis; Randomized-controlled trial. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. This result is consistent with evidence that the GSM lipid fraction contains various lipid bioactives and unique fatty acids such as tetraenoic acids with great anti-inflammatory activity (Sinclair et al. Pregnancy and lactation, a challenge for the skeleton. An official website of the United States government. Overall, this study concluded that the GSM lipid extract was a safer alternative and resulted in faster and more notable treatment effects with smaller dosages compared with fish oil. Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Butyrate can also be converted back to actatate by sulfate- or nitrate-reducing acetogenic bacteria [63]. FOIA Coulson S, Butt H, Vecchio P, Gramotnev H, Vitetta L. Inflammopharmacology. BMJ. Consistent with this study, an RCT by Zawadzki et al. To interpret whether the effect size was clinically important, a threshold of 0.37 standardised units was considered as the minimum clinically important difference (MCID); this is based on the previous reviews (da Costa et al. Gazette Medicale. Juliano C., Manconi P., Cossu M. Characterisation of commercial perna canaliculus samples and development of extemporaneous oral veterinary paste formulations containing perna. 8600 Rockville Pike There is also evidence, suggesting that oestrogen therapy reduces risks of joint symptoms (Chlebowski et al. While the metabolism of GLM extract is yet to be investigated comprehensively, preliminary in vitro studies have confirmed that GS extract is fermented and metabolized by commensal intestinal bacteria [15,16,66]. The greatest improvements from week 4 associated with GSM lipid were in the VAS pain perception and patients global assessment of arthritis. Production of butyrate from lysine and the amadori product fructoselysine by a human gut commensal. ), 2Medlab Clinical, Sydney 17200, Australia; oc.baldem@llah_naes. P. canaliculus has been demonstrated to indirectly target the intestinal microbiota and in part influence intestinal bacterial biodiversity, growth and metabolic activity [17]. and M.T. Front Med (Lausanne). The https:// ensures that you are connecting to the Schloss P.D., Girard R.A., Martin T., Edwards J., Thrash J.C. Osteoarthr Cartil. Symbiotically, the intestinal tract and the residing bacterial populations comprise one of, if not the most, metabolically and immunologically active organs in the human body [7]. Seven of the nine included trials were parallel and randomized-controlled trials (Audeval and Bouchacourt 1986; Coulson et al. Of these 11 studies, two did not meet the inclusion criteria and were excluded: one study administrated GSM in both the intervention and comparator group (placebo) (Puente et al. 1980). Highton T.C., McArthur A.W. These systematic reviews were conducted on only four or five randomized-controlled trials (RCTs). McPhee S, Hodges L, Wright P, Wynne P, Kalafatis N, Harney D, Macrides T. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. 2010 Sep 16;341:c4675 official website and that any information you provide is encrypted Clostridia, previously established as a potent modulator of Th17 and CD4+ regulatory cells, correlates with inflammation and Gastrointestinal Symptom Rating Scale (GSRS) scores and OA symptoms [17]. Wakimoto T., Kondo H., Nii H., Kimura K., Egami Y., Oka Y., Yoshida M., Kida E., Ye Y., Akahoshi S., et al. It is this blockage in COX pathways that is linked with reduced levels of multiple pro-inflammatory cytokines, including interleukin (IL) 1, IL-2, Il-6 and tumor necrosis factor alpha (TNF-alpha) [22]. By modifying the bioactive components of food, the intestinal microbiota can influence the exposure to nutrients that have health or disease modifying potential [17]. This site needs JavaScript to work properly. Mani S., Lawson J.W. E. rectale and Roseburia spp. Specifically, the Perna canaliculus species has been repeatedly demonstrated to harbor anti-inflammatory compounds such as omega-3 polyunsaturated fatty acids ( -3 PUFAs) that can ameliorate pro-inflammatory conditions, or proteins that can promote thrombin inhibitory activity. A large group including Bacteroides, Proteobacteria, Bifidobacteria, Clostridia, and Eubacteria produce acetate. Cresol biodegradation pathway along the ortho (catechol) pathway [23]. 2012, 2013; Gibson et al. Clinical data demonstrating efficacy for nutraceutical compounds marketed for the symptom relief of osteoarthritis (OA) have been largely contentious. Objectives: 2000). and transmitted securely. Lyprinol was also associated with less severe histological damage with the intestines having longer crypts and increased proliferation in the midsection of the small intestine compared to controls (p < 0.05), although it was unable to prevent 5-FU-induced weight loss, decreased feed intake and the weight of thymus and spleen [69]. The site is secure. Distribution Abshirini M, Coad J, Wolber FM, von Hurst P, Miller MR, Tian HS, Kruger MC. Dysbiosis, a gut barrier abnormality of the intestinal epithelia, may also play a central role in nutraceutical efficacy to help ameliorate these conditions. Therefore the current perception of prebiotics indeed refers to those compounds categorized as non-digestible food ingredients or substances (Figure 1), which pass undigested through the proximal part of the intestine (small bowel) and stimulate the growth and activity of health-promoting commensal bacteria that almost intuitively colonize the large bowel [9]. Following tandem delivery, paw swelling was significantly reduced in rats with adjuvant-induced arthritis and zymosan-induced paw inflammation [35]. Janczyk W., Socha P., Lebensztejn D., Wierzbicka A., Mazur A., Neuhoff-Murawska J., Matusik P. Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: Design and rationale of randomized controlled trial. A few studies have assessed the efficacy of GSM lipid extracts in treating OA. ); ua.ude.yendys.inu@2590ohtm (M.T. 2007. General characteristic of the studies included in systematic review, 7. 2013). The synergystic effects of omega-3 fatty acids against 5-fluorouracil-induced mucosal impairment in mice. The https:// ensures that you are connecting to the Wakimoto T, Kondo H, Nii H, Kimura K, Egami Y, Oka Y, Yoshida M, Kida E, Ye Y, Akahoshi S, Asakawa T, Matsumura K, Ishida H, Nukaya H, Tsuji K, Kan T, Abe I. Proc Natl Acad Sci U S A. Furthermore, GSM is reported to contain novel bioactive lipids such as pro-resolving lipid mediators which resolve inflammation through counter-regulating pro-inflammatory cytokines, clearing apoptotic neutrophils, and inducing wound healing and tissue regeneration (Wakimoto et al. Understanding the impact of omega-3 rich diet on the gut microbiota. PMC 2012). Bannuru RR, Osani M, Vaysbrot E, Arden N, Bennell K, Bierma-Zeinstra S, Bhandari M. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. 2008 Mar;101(3):167-79. doi: 10.1093/qjmed/hcm108. Fermentation of dietary fibers by anaerobic intestinal microbiota produces short-chain fatty acids (SCFAs). Two studies did not specify the joint location (Gibson and Gibson 1998; Gibson et al. A literature search of the three databases EMBASE, MEDLINE, and Scopus was performed to identify relevant articles published up to March 2020. This systematic review evaluates the efficacy of the nutritional supplement Perna Canaliculus (green-lipped mussel, GLM) in the treatment of OA and substantially adds to previous work by focussing solely on GLM use in OA as well providing a re-analysis of the original trial data. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial. Table 1 details randomized clinical trials that have investigated the effect of P. canaliculus supplementation in the treatment of arthritic diseases. Ulbricht C, Chao W, Costa D, Nguyen Y, Seamon E, Weissner W. An evidence-based systematic review of green-lipped mussel (Perna canaliculus) by the natural standard research collaboration. Outcome measures were scored using the WOMAC, the Lequesne algofunctional index, and the Gastrointestinal Symptom Rating Scale (GSRS) tools. A repeated measures ANOVA analysis showed significant improvement in scores for the Lequesne (F = 20.317, p < 0.001), WOMAC (F = 28.383, p < 0.001) and the GSRS (F = 9.221, p = 0.002). Metabolic benefits of dietary prebiotics in human subjects: A systematic review of randomised controlled trials. This site needs JavaScript to work properly. Careers, Unable to load your collection due to an error. Whitehouse M, Macrides T, Kalafatis N, Betts W, Haynes D, Broadbent J. Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel. The analyses were performed using STATA version 14 (StataCorp, College Station, TX, USA). Animals with early life stress, induced by maternal separation, have been shown to develop dysbiosis characterized by a decreased ratio of Bacteroidetes to Firmicutes and the induction of inflammatory cytokines in plasma. We considered the treatment effect small if the effect size was<0.3, moderate if the effect size was between 0.3 and 0.8, and large if the effect size was>0.8. Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menndez C, Moraleda C, Rogers L, Daniels K, Green P. Cochrane Database Syst Rev. Glucosamine utilization by some lactic acid bacteria. Such a shift in the microbial configuration provides a possible explanation as to how -3 PUFA supplementation ameliorates acute and chronic diseases associated with intestinal epithelial dysbiosis. A randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of a novel green-lipped mussel extract -BioLex -for managing pain in moderate to severe osteoarthritis of the hip and knee. The activation of FFAR2 and FFAR3 stimulate the release of glucagon-like peptide-1 (GLP-1) and gut hormone peptide YY (PYY) in the intestine, improving insulin secretion. However, a significant improvement in the VAS pain scale was observed only in the whole GSM powder group as 70% of patients benefited from it. In this study, all the arthritis assessment parameters, including VAS, patients and physicians global assessment of arthritis, a validated Chinese version of the Oxford Knee Score (COKS), and a validated Chinese version of the Arthritis Impact Measurement Scale 2-short form (CAIMS2-SF) that assessed physical function and psychological status, were significantly improved in the lipid extract group. Chlebowski RT, Cirillo DJ, Eaton CB, Stefanick ML, Pettinger M, Carbone LD, Wactawski-Wende J. Estrogen alone and joint symptoms in the Womens Health Initiative randomized trial. official website and that any information you provide is encrypted From the rudimentary analysis of fecal samples by Coulson et al. Altman RD. and transmitted securely. Four studies were excluded, because they did not assess the VAS as outcome or were non-controlled clinical trials. 2022 Dec 5;9:1063336. doi: 10.3389/fmed.2022.1063336. The genera of bacteria that are consistently reported as key for producing and maintaining health-promoting activities in the prebiotic literature are largely limited to the Lactobacillus and Bifidobacterium genera. These findings of the potency of whole mussel extract powder has provided the impetus for integrating marine peptides into novel pharmaceutical developments [42]. Interestingly, both studies showed that GSM whole extract powder significantly attenuated the detrimental gastrointestinal aspects assessed by GSRS scores, which are linked to the long-term use of NSAID medications. Approximately 70% of an extract of whole mussel P. canaliculus is protein. A flowchart of the search strategy and selection process is displayed in Fig. Based on the total awarded score, studies with 02.5 scores were categorised as low quality and studies with 35 scores were defined as high quality (Table (Table11). The GSM extract was considered to be generally well tolerated in most of the studies. DHA was reported as more beneficial than EPA with the combination having the best effects. A diet rich in the fish fatty acids EPA and DHA for 15 days decreased Helicobacter, Clostridiales bacterium, Sphingomonadales bacterium and Pseudomonas species Firmicutes in mice [56], while a diet rich in sardines for six months (100 g sardines providing 3 g EPA and DHA) was shown in 35 drug-nave patients with type 2 diabetes to be associated with a shift in the intestinal microbiome. -. 2022 Aug 8;26(4):166-173. doi: 10.1080/19768354.2022.2106302. FOIA doi: 10.1530/EC-20-0055. MeSH Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol. A variety of product preparations and different dosages were evaluated. 2007). [17], the study showed that Bacteroides (a genus of Gram-negative, obligate anaerobic bacteria) as a group were increased at the end of the P. canaliculus supplementation period, indicating that P. canaliculus possibly increased SCFA-producing intestinal bacteria. (in vitro, animal research, human data). Stebbings S, Gray A, Schneiders AG, Sansom A. BMC Complement Altern Med. -, Brien S, Prescott P, Coghlan B, Bashir N, Lewith G. Systematic review of the nutritional supplement Perna Canaliculus (green-lipped mussel) in the treatment of osteoarthritis. Moreover, these studies did not provide information on the dose of NSAID medications used by the participants, and generally were of low quality and lacking in rigorous methodology (Whitehouse et al. A horizontal line representing the 95% confidence intervals of the study result, with each end of the line representing the boundaries of the confidence interval. Alternatively, the GSM product used in this study may have lacked specific bioactive lipids; in previous studies that obtained positive results with high doses of freeze-dried powdered products (Coulson et al. All recruits were middle-aged or elderly, and all studies included participants of both sexes, but females predominated (nearly 80%). Blocking arachidonic metabolism through cyclooxygenase (COX) and lipoxygenase pathways, P. canaliculus can efficiently block the action of COX-1 and COX-2 enzymes via a dose-dependent mechanism. Gibson G, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Lipids were extracted using acetone, which was followed by protein extraction using the broad-spectrum enzyme Alcalase and then carbohydrate extraction using cetylpyridinium chloride. PMC The researchers suggested that significant pain improvement was not detected due to the severity of disease in this cohort, as half of the patients had moderate-to-severe OA. The linseed/fish oil diet triggered significant growth in the genus level of Bifidobacterium compared to mice fed a low-fat high-maize starch diet (p < 0.05) [58]. Synergism of 5-FU and fish oil was also reflected in significant inhibition in tumor growth in a model of colon cancer. The .gov means its official. 2017; Zawadzki et al. 2014; Litwic et al. P. canaliculus has been utilized in the design of commercial therapeutic agents of arthralgia in humans and animals alike. Bui T.P., Ritari J., Boeren S., de Waard P., Plugge C.M., de Vos W.M. Numerous bacterial species are involved in the production and interconversion of SCFAs. Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health. B Biochem. Federal government websites often end in .gov or .mil. Early management of osteoarthritis. 2011 Jan;82(1):53-66 2017; Zawadzki et al. Before There are no published reports identifying significant differences in treatment outcomes based on joint location, and a study of gene expression comparing OA versus normal cartilage found that the genes associated with OA were not correlated with the joint site (Ramos et al. Early studies with murinae models have shown that the lipid-rich fraction of the GLM exhibits synergistic anti-inflammatory properties that are characteristic of immunomodulation when administered in combination with oral non-steroidal anti-inflammatory drugs (NSAIDs) and analgesic medications including prednisone, pentoxifylline or meloxicam [34,35]. SCFAs serve as a source of energy for epithelial cells but also act as signaling molecules. Careers. The metabolic capacity of intestinal microbiota can modify bioactive food components altering the hosts' exposure to these components, potentially enhancing or diminishing their health effects. HHS Vulnerability Disclosure, Help HHS Vulnerability Disclosure, Help Perna canaliculus (Green-Lippped Mussel) is found only in New Zealand waters and is cultivated and manufactured for both the food and nutraceutical industry world-wide. The -3 PUFA portion has been suggested to be responsible for helping to reduce risk factors associated with cardiovascular disease, as well as helping to relieve symptoms of inflammatory disorders like OA [44]. -. The underlying mechanisms explaining these effects are in the anti-inflammatory activity of bioactive lipids in mussels including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This shift in the intestinal microbial composition and increased production of SCFA, particularly butyrate, is associated with anti-inflammatory, anti-microbial and immunomodulatory effects. What Are Green Lipped Mussels? The Effects of PCSO-524, a Patented Marine Oil Lipid derived from the New Zealand Green Lipped Mussel ( Perna canaliculus), on Pulmonary and Respiratory Muscle Function in Non-asthmatic Elite Runners Int J Exerc Sci. 2006 May;25(3):275-84. doi: 10.1007/s10067-005-0001-8. The https:// ensures that you are connecting to the 2008; Cobb and Ernst 2006; Ulbricht et al. This study suggests that the mussel meat powder may serve to control metabolic and immunity activity of the intestinal microbiome. SCFAs in the gut are in a state of flux. official website and that any information you provide is encrypted The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 1980). A total of nine clinical trials were included in systematic review, from which five studies were considered appropriate for inclusion in a forest plot. New Zealand green-lipped mussel might. We report for the first time that the administration of GLM extract also significantly improved GI symptoms by 49% in OA patients. This systematic review summarises the efficacy of GSM extracts in the treatment of OA. The eligibility criteria were: randomized-controlled or randomized non-controlled clinical trials; the GSM supplement was used as intervention in the form of lipid extract or freeze-dried whole powder (not in combination with other constituents with anti-inflammatory or anti-arthritic activity); the patients/participants were diagnosed with OA by radiography and outcomes of interest relevant to OA were assessed. However, the current evidence is limited by the number and quality of studies, and further larger and high-quality studies are needed to confirm the effectiveness and to identify the optimal GSM format. the contents by NLM or the National Institutes of Health. 1980). A p value<0.05 was considered statistically significant. Accessibility Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Foley S., Stolarczyk E., Mouni F., Brassart C., Vidal O., Aissi E., Bouquelet S., Krzewinski F. Characterisation of glutamine fructose-6-phosphate amidotransferase (ec 2.6.1.16) and n-acetylglucosamine metabolism in bifidobacterium. Ghosh S., DeCoffe D., Brown K., Rajendiran E., Estaki M., Dai C., Yip A., Gibson D.L. The https:// ensures that you are connecting to the 2009;6(1):54-90. doi: 10.1080/19390210802690191. A number of bioactive compounds from the Mytilus and Perna genuses are found within the P. canaliculus species extract, which is emerging as the most carefully and intensely investigated compound for medicinal and therapeutic effects. Roberfroid M., Gibson G.R., Hoyles L., McCartney A.L., Rastall R., Rowland I., Wolvers D., Watzl B., Szajewska H., Stahl B., et al. The diet was associated with longer villi compared to controls. Effects of d-002, a mixture of beeswax alcohols, co-administered with green-lipped mussel extract, on osteoarthritis symptoms.